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Ipamorelin acts through GHS-R1a, whereas compounds such as CJC-1295 and Sermorelin target the growth hormone-releasing hormone receptor (GHRHR)
namely, maximal (1 M agonist) cAMP production increased as maximal internalization fell, but reached a plateau beyond which further decrease in internalization did not yield additional increase in cAMP efficacy
While these accounts offer valuable insights, they fall short of the rigorous, controlled observations provided by clinical trials and thus must be approached with caution
doi:10.4103/jrms.JRMS_862_18 De Bruyn E, Gulbis B, Cotton F
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