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Emerging Competition: The pipeline is active, and newer agents with potentially improved profiles (e.g., oral formulations, novel mechanisms, or triple agonism) could emerge

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Indeed, preclinical studies have shown that tirzepatide can restore synaptic integrity by increasing the expression of postsynaptic density protein 95 (PSD-95) and synaptophysin and can promote the formation of dendritic spines the morphological basis of synaptic plasticity []