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Patient compliance and maximal efficacy of GLP-1 therapeutics are limited by side effects including nausea and emesis

GLP1, also known as 7-37 for the codons of the preproglucagon molecule which encode it, renders pancreatic beta-cells 'glucose-competent' and may be useful in the treatment of noninsulin-dependent diabetes mellitus

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In practice, most clinicians would likely taper tirzepatide down before initiating retatrutide to manage overlapping GI side effects and assess the new compound's individual response