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The H -score ranged from 0-300 and the optimal cutoff value for it was defined via the largest Youden index under the receiver operating characteristic (ROC) ( Cell Culture PC cell lines (MIA PaCa-2, PANC-1, CFPAC-1, T3M4, BxPC-3, and AsPC-1) were obtained from the American Type Culture Collection (Virginia, USA)

Moreover, a total of 18 microbial pathways were less abundant as the NR increased

GLP1 agonists are known to enhance both cardiovascular and renal outcomes

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Activation of both GIP and GLP-1 receptors by retatrutide probably contributed to the observed changes in circulating triglycerides, as treatment with the dual GIP/GLP-1 receptor agonist tirzepatide significantly reduced triglyceride levels by up to 29% at 52 weeks in a clinical trial in people with T2D and MASLD 8