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Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4

Benefits of B12 injections include the following: Might Reduce Depression, Cognitive Decline and Dementia: Some studies show that, especially in older people, supplementing with vitamin B12 can help prevent depression, restore better mood control and retain healthy memory/mental functioning

doi:10.1016/S2213-8587(21)00179-0

Prescribing physicians use a patients medical history and sometimes even initial and ongoing biomarker testing to assess candidacy

So ME/CFS is on the spectrum of POTS it's just that they haven't necessarily met the heart rate criteria for POTS