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Effective contraception is essential during treatment, as these medications are contraindicated in pregnancy, with a recommended washout period (approximately 2 months for semaglutide) before planned conception

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Indeed, both in rodents and humans, GLP-1 infusion increased fractional sodium excretion [20], which has been linked to the finding that sodium is more rapidly excreted following an oral versus equivalent IV sodium load in a number of experimental studies in healthy individuals, independent of factors such as atrial natriuretic peptide (ANP) and aldosterone [22]