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355 Ji et al
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Here are some detoxification methods to consider: 1
The nasal spray format is particularly interesting for circadian research because evening administration timed to coincide with the natural onset of melatonin secretion delivers epitalon to the brain via nose-to-brain pathways at the moment when pineal melatonin production should be increasing
Patients with contraindications or non-responsive to NSAIDs may benefit from opioids such as meperidine [114], butorphanol [115], or hydromorphone [110]
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