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This phenomenon, sometimes referred to as early worsening of diabetic retinopathy, appears to be related to the magnitude and speed of glucose lowering rather than a direct effect of the medication

roughly 50-98 % of an administered dose is renally excreted unmetabolized, underscoring the low intrinsic toxicity

Porphyria is a rare metabolic disorder that affects blood composition

Potential for resistance or adaptation Whether the body adapts to NNMT inhibition over time is unknown

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