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Approved agents like suvorexant (Belsomra) and low-dose doxepin have Phase III RCT data in hundreds to thousands of patients
[Abstract]2022 Sep;150(3):727-735.e6
Note: Holtorf co-founded Integrative Peptides which sells oral BPC-157
A randomized, double-blind, placebo-controlled trial published in the European Journal of Nutrition found that daily oral glutathione supplementation at 1,000 mg for six months increased glutathione levels by 30 to 35% in erythrocytes, plasma, and lymphocytes among 54 healthy adults
Outcome Over the following weeks most people notice deeper, more restorative sleep first (weeks 12), then steadier energy, better recovery, and clearer thinking (weeks 24), then a broader sense of vitality with skin and hair improvements for some (weeks 412)
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