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The tri-agonist was tenfold more active than individual native hormones at all three receptors in vitro, and was more effective than a GLP-1R/GIPR co-agonist at lowering body weight in DIO mice [92]
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Injections are given subcutaneously abdomen, thigh, or upper arm are best
In contrast, Bydureon is a long-acting, once-weekly formulation, developed using a microsphere-based delivery system
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