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A systematic review ScienceDirect science/article/pii/S2214623724000048 [64] What is the pipeline for future medications for obesity
By activating GLP-1, GIP, and glucagon receptors simultaneously, it produces a distinct metabolic effect profile that combines the appetite and insulin effects of GLP-1/GIP activation with the energy-expenditure effects of glucagon receptor activation
Repeating this process over and over causes worsening leptin resistance - so that you are unable to lose weight even if you try excessive dieting or calorie restriction
Poor transitions lead to unnecessary side effects, potential safety risks, and suboptimal results
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