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Changes in levels of plasma DPP-4 activity could, therefore, be related to overall changes in the total expression of DPP-4 and/or simply altered shedding from cell membranes
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Skinner AC, Staiano AE, Armstrong SC, et al
Still, strong safety data is a different claim than proven efficacy, and AOD-9604 currently has the latter unresolved while the former is well established
Lack of regulatory guidance: Clinicians must obtain informed consent and monitor closely for safety, tolerability, and efficacy
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