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Widgerow AD, Ziegler ME, Shafiq F
Additional data were gathered on covariate adjustment strategies (e.g., age, sex, and metabolic disorders) and relevant medical histories (e.g., obesity, type 2 diabetes mellitus)
This means your body can typically produce sufficient amounts, but certain conditions like growth, injury, or illness may increase requirements beyond what your body can synthesize
They work through different mechanisms, carry different risk profiles, and serve different patient needs
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