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These include (1) tetrahydrobiopterin (BH 4 ), synthesized by the GTP cyclohydrolase 1 (GCH1)6-pyruvoyl-tetrahydropterin synthase (PTS)sepiapterin reductase (SPR) metabolic pathway and regenerated by dihydrofolate reductase (DHFR) 11
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89 Acetylation Lactylation interacts synergistically or through competitive inhibition with acetylation
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