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NICE Technology Appraisal guidance (TA875 for semaglutide/Wegovy and TA664 for liraglutide/Saxenda) recommends these medications for weight management in adults with: A body mass index (BMI) of at least 35 kg/m and At least one weight-related comorbidity (such as type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea, or non-alcoholic fatty liver disease) For liraglutide (Saxenda), NICE TA664 specifies additional criteria including prediabetes (HbA1c 42-47 mmol/mol or fasting plasma glucose 5.5-6.9 mmol/L) or high risk of cardiovascular disease

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Using this criterion, we found that MIF (encoding macrophage migration inhibitory factor, 1.4 logfold increase in -1), SERPINA1 (encoding -1-antitrypsin, 0.8 logfold increase in -1, 0.4 logfold increase in -2), REG1A (encoding lithostathine-1-, 0.6 logfold increase in -2), and GLS (encoding glutaminase, 0.7 logfold increase in -2) are the genes encoding a secreted protein with the greatest increase in cells in response to liraglutide treatment (Supplemental Table 2)