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(PubMed) Havemeyer A, Bittner F, Wollers S, Mendel R, Kunze T, Clement B
Poller, W
The level of oxidative stress in the brain of schizophrenic patients is significantly higher than that of the normal population, and the level of enzyme and non-enzymatic antioxidants is significantly decreased, especially in the acute phase, when the symptoms of hallucinatory delusions are obvious, and the organisms oxidative stress damage is more severe relative to the smooth phase
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High levels of saturated free fatty acids can cause ER stress that activates the UPR pathway by various mechanisms, such as inhibition of the enzyme that mobilizes ER Ca 2+ (i.e., ER Ca 2+ ATPase), activation of IP3 receptors, and/or directly impairing ER homeostasis (241)
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