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Many patients begin therapy believing the injection will do all the work
Avoid opioid pain medications and frequent NSAID use with semaglutide due to compounded effects on stomach motility and serious GI risks
For continuation: evidence of at least 3 months on a stable dose and at least a 5% weight loss (for Wegovy/Zepbound), or 4% for Saxenda
Washout duration scales with the preceding cycle length: 4-week washout: Minimum threshold, appropriate after an 8-week cycle
The critical difference from patches is the delivery route
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