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Hand-searching of reference lists on key papers and web-based search of the grey literature, such as Google Scholar and professional and government websites were performed with the same terms used for the published articles
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Thus the best-known "function" of B 12 (that which is involved with DNA synthesis, cell division, and anemia) is a facultative function that is mediated by B 12 -conservation of an active form of folate which is needed for efficient DNA production
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However, the full scope of its efficacy and safety is still under investigation
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