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This is a common concern, and the clinical reality is that without a maintenance phase, some weight regain is possible because the bodys natural hunger signals will return
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These GLP-1 receptor agonists are highly effective: they reduce appetite, regulate blood sugar, and lead to significant weight loss
doi: 10.3389/fimmu.2018.01291 15 GrahamDLMadkourHSNobleBLSchatschneiderCStanwoodGD
Scenario 1: Planned Discontinuation With Good Outcomes The best-case scenario: Made substantial lifestyle changes during treatment Achieved modest, sustainable weight loss Eating patterns feel genuinely different, not forced Exercise is established routine Weight remains stable after stopping (within 5-10% of lowest) Maintained vigilance catches any creep early What this looks like: You stop medication and appetite returns but is manageable You maintain most of your weight loss through established habits Some weight returns but you stabilize at an acceptable level Years later, youre still at a significantly lower weight than baseline Likelihood: This represents the minority of patients
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