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NICE states that semaglutide can be used alongside a reduced-calorie diet and increased physical activity, up to a maintenance dose of 2.4 mg once weekly, in adults with established cardiovascular disease and a BMI of at least 27 kg/m

That being said, coverage for weight loss drugs is sometimes limited unless the patient has a comorbid condition, like sleep apnea, high blood pressure, or high cholesterol

This is not equivalent to a higher approved doseit bypasses the gradual titration protocol designed to monitor tolerability and adjust if nausea, vomiting, or other gastrointestinal effects become problematic

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John Buse (UNC) noted, weight regain after stopping GLP-1 therapy almost always happens within a year and, if these results translate to humans in future studies, TIX100 could address a critical gap in long-term obesity management