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What they found: Dose-dependent stimulation of type II collagen (up to 2.5 baseline at 100 nM) Stimulation of aggrecan (up to 1.8 baseline) Inhibition of MMP-13 by ~40 % Partial protection against IL-1-induced matrix degradation Why it matters: It opened a completely new research area for AOD-9604 beyond lipolysis
Furthermore, the markers associated with terminal skin cell differentiation (filaggrin and loricrin) increase with age, while the markers indicating epidermal proliferation decline (Ki16 and Ki67)
The short answer: they are answers to different questions
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