This observation has raised concerns regarding suboptimal drug exposure, altered pharmacokinetics, and heightened inflammatory burden in obese patients, highlighting the potential need for dose optimization or alternative treatment strategies in this population ( The impact of BMI on treatment response is well illustrated by the AQUILA study, which examined real-world outcomes in PsA patients treated with ( However, the relationship between BMI and response to biologic therapies is not uniformly consistent across studies
Oestrogen, progesterone, insulin and cortisol all influence appetite, metabolism and fat storage
2 Visceral fat, found around vital organs like the liver and pancreas, raises inflammation and accelerates biological aging more than subcutaneous fat, which resides just under the skin
The same trend was seen in a 2021 study published in The New England Journal of Medicine
Starting retatrutide at 1 to 2 mg is reasonable