These landmark studies established that GLP-1 medications deliver clinically significant results in non-diabetic populations, leading to FDA recognition of semaglutide and tirzepatide as weight loss agents independent of diabetes status
The medication is indicated for adults with a body mass index (BMI) of 30 kg/m or greater, or 27 kg/m or greater with at least one weight-related condition such as hypertension, type 2 diabetes, or dyslipidemia
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The clinical relevance of these results seems also highlighted by the evidence that for some outcomes the clinical benefit is consistent irrespective of the presence of type 2 diabetes [13], advanced age [13, 30], and the background cardiorenal disease [12, 15, 31]
Forbes AK, Suckling RJ, Hinton W, et al