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Furthermore, increased circulating levels of UA have survival advantages by maintaining blood pressure, improving reaction time and mental performance, and preventing infections or tumors [19]
A number of aging-related phenotypes are also delayed in these mice, including collagen cross-linking, cataract development, kidney diseases, fatal neoplastic diseases and decline in immune function, locomotor activity, learning and memory (Bartke, 2011)
CPP-CAND exhibits selective senolytic activity Doxorubicin is known to induce senescence in the A375 melanoma cell line 25
On the molecular level, drug treatments restored the antioxidant capacity, ameliorated hippocampal A, TGF-1, and p-Smad2 protein levels, amended p21 gene expression, and restored the histopathological insults
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