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Sitagliptin in Combination with Metformin and Rosiglitazone In a placebo-controlled study of sitagliptin 100 mg as add-on therapy in patients with type 2 diabetes inadequately controlled on metformin and rosiglitazone (sitagliptin, N=181
Therefore, the risk to humans is uncertain and those with a personal or family history of medullary thyroid carcinoma should avoid GLP-1 receptor agonists unless otherwise advised
That doesnt change much when it comes to the net effects
crosses the BBB & produces CNS effects such as tremor, choreiform movements, and mental aberrations
Endocrinology 151(6):26292640
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