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la FDA no evala su seguridad o eficacia antes de su comercializacin Tericamente podran influir en la produccin endgena de GLP-1, pero este efecto no est clnicamente validado Son considerablemente menos costosos ($20-60 mensuales) La distincin regulatoria es crtica: bajo DSHEA, los suplementos probiticos no pueden legalmente afirmar que tratan, previenen o curan enfermedades, mientras que los medicamentos tienen indicaciones teraputicas especficas aprobadas

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Our studies have some limitations, including the use of two distinct promoters to drive cre expression for targeting Gipr versus Glp1r in the brain, and the non-CNS exclusive pattern of Wnt1 expression, which also targets the enteric nervous system

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