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These findings align with preclinical data showing that circadian disruption enhances TNBC tumor growth and impairs the time-dependent efficacy of cisplatin therapy, suggesting that both intact circadian signaling and melatonin rhythms are crucial for optimizing chemotherapeutic outcomes 58
Image stacks (0.2 m distance) were acquired with a Leica microscope equipped with an 100 oil-immersion objective and a Leica DFC 365 FX camera using Leica AF6000 software
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