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An open-label study (n=42) found that IV NAC (50 mg/kg) combined with oral NAC (500 mg twice daily) for 3 months increased brain glutathione levels (measured by MRS), increased dopamine transporter binding (measured by DaTscan), and improved UPDRS motor scores (Monti et al., PLoS One, 2016) [53]

The GLP-1 family acts heavily on the gut-brain axis through slowed digestion and reduced hunger signalling

The bioavailability difference between the two routes compounds the distinction: topical application creates a localized skin depot, while injection delivers the peptide systemically at concentrations impossible to achieve through the skin barrier

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Since most chemotherapeutic agents increase intracellular ROS levels [47], TIC resistance may stem from their high antioxidant content, including glutathione