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Benefits attributed to sustained IGF-1 levels maintaining muscle protein synthesis rates throughout the day
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We suggest a dose of 250300 mcg daily
Further research, including long-term evaluation of sarcopenia in GLP-1RAs trials, development of standardized monitoring protocols and investigation of combined nutritional, exercise and pharmacologic strategies, is needed in order to prevent muscle loss while maximizing metabolic benefits under GLP-1RAs treatment
Oxidative stress is associated with redox reactions involving hemoglobin (Hb), nitrite, and nitric oxide (NO), leading to the formation of highly toxic peroxynitrite when NO reacts with superoxide released during Hb autoxidation (10)
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