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Although the exact mechanisms are still being investigated, the cumulative effect of ZNF259 gene mutations in a polygenic context underscores its role as one of several genes with moderate effects on obesity susceptibility and metabolic dysregulation in affected individuals ( Weight loss medications: scientific findings and clinical studies The development of pharmacological agents for weight loss has intensified over the past decade, with several classes of anti-obesity medications targeting metabolic, hormonal, and appetite-regulating signaling pathways

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Polar metabolites By analyzing the production of polar metabolites (Fig