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doi: 10.1007/s13300-018-0428-y 133 McCartneyFGleesonJPBraydenDJ

Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core

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By engaging multiple incretin pathways simultaneously, it has become a subject of interest in metabolic and endocrine research