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GLP-1 receptor activation does several things

First, the ligand-binding pocket is split into two distinct regions, forming a bifurcated pocket. Within this pocket, a salt bridge between Glu124 3.33 and Arg283 6.55 [superscripts denote the BallesterosWeinstein numbering system (Ballesteros and Weinstein, 1995)] divides the ligand-binding pocket into two cavities: a relatively large Cavity I and a smaller Cavity II (Figure 2B)

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This study provides evidence for a specific, measurable functional improvement from FOXO4-DRI treatment and demonstrates the peptide's senolytic activity outside the original Erasmus University research group