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it is likely that these will be above the normal range and do not necessarily show any correlation with the symptoms experienced by patients[2,11]
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To comprehensively understand the gene expression changes responsible for the differences in dTTP and GSH biosynthesis, we performed RNA sequencing analysis of WT- and T315I-Bcr-Abl-32D cells
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The slow titration (125 mcg weeks 1-4, then 250 mcg weeks 5-8) mimics FDA-approved protocols that emphasize gradual increases for tolerability
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