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Gastrointestinal changes are common
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The safety profile remained consistent with previous studies, with gastrointestinal effects being the most common adverse events, typically occurring during the dose-escalation period in the first 20 weeks.The SURMOUNT-1 trial demonstrated that tirzepatide significantly improved various cardiometabolic risk factors beyond weight reduction and diabetes prevention
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Use of institutional data warehouses, contributing 85% of cases, helped limit recall bias, though biological markers, including glycaemic indices, were unavailable, restricting mechanistic insight
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