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For example, the roles of genetic predisposition, age, and comorbidities in modulating susceptibility to neurotoxicity remain underexplored
10.1016/j.foodchem.2017.09.046 Food Chem
Only a small, yet significant amount is metabolised via the hepatic cytochrome P450 enzyme system (its CYP2E1 and CYP1A2 isoenzymes), which is responsible for the toxic effects of paracetamol due to a minor alkylating metabolite ( N -acetyl- p -benzo-quinone imine, abbreviated as NAPQI)
It is estimated that up to 92% of the US population is either chronically dehydrated or vitamin deficient
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