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Updated March 2026

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Andrew Shapiro, MD, a surgeon at Advanced Surgical Physicians, says, Other side effects include hard nodules under the skin, which happen when the medication isnt evenly absorbed, infections that occur when bacteria enter through the injection site, and fatty tissue buildup under the skin caused by repeatedly injecting in the same spot. Tell your healthcare provider if any of the following occur: Blistering around the injection site Redness or swelling thats more than 2 inches in diameter Severe pain, itching, or bleeding at the injection site Flu-like symptoms, including fever, muscle aches, nausea, dizziness, or vomiting Worsening reactions every time you take Mounjaro Symptoms dont go away within three days Symptoms are typically isolated to a small area around the injection site