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As positive controls, PSCs were pre-incubated with Rosup reagent (Beyotime) for 20 min
Reported side effects are rare and typically mild: mild redness or irritation at the application site (usually resolves with continued use or concentration adjustment), occasional skin tingling at higher concentrations (typically benign), and temporary dryness during initial use
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The following sgRNAs for GGT1 CRISPRi were used: sgGGT1 1 (HL-ID: 3) forward: 5-CACCGGTGCCTCCCACTGTCCGCCG-3
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Adenosine and hyaluronic acid enhance skin elasticity and hydration, while the patented Multi Ex BSASM Plusfeaturing seven botanical extracts like rosemary, chamomile, and green teasoothes and strengthens the skin barrier
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