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Molecules 26 , 6525 (2021)
PMID 28775711
With opioids, the neurotransmitter serotonin has also been extensively investigated for its role in the pathophysiology of ASD in the CNS [272, 569] and its ability to modulate neural plasticity and networks [311]
In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]
E.LayfieldR.et al (2010)
