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Published pharmacology studies on Ipamorelin (Raun and Ankersen, PMID 9849822 and PMID 9733495) report a "clean endocrine profile," meaning it did not significantly raise ACTH, cortisol, or prolactin in those trials, unlike older, less-selective GH secretagogues

Exendin-4 then proved safe and effective in humans, leading to the 2005 US Food and Drug Administration (FDA) approval of exenatide, under the name Byetta

They also looked at parts of the mices brains that are believed to be connected to nausea when taking GLP-1 and found no increased activity when those proteins were stimulated, while mice who were only given the drug did show a significant jump in that part of their brains

10.1016/j.stem.2008.01.014 26 InoueM