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When the benefit outweighs the side effect, and when it might not For most patients, the metabolic benefits of GLP-1 therapy, including improved cardiovascular risk factors, better insulin sensitivity, reduced visceral fat, and meaningful weight loss, far outweigh a temporary or modest change in libido

It burns whatever is available, and muscle is an expensive tissue to maintain

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A controlled clinical trial of over 2,500 obese or overweight people was conducted to assess the effectiveness of tirzepatide

During the COVID-19 pandemic, individuals with thyroid diseases (mostly autoimmune) showed lower adherence to the MeD, higher prevalence of overweight, and reduced physical activity compared with controls, further supporting the benefits of healthy lifestyle choices [176]