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This differential efficiency of reprogramming was also reflected in the transcriptomes of these cells, as evaluated by the enrichment of a reprogramming score composed of genes previously reported in MEFs that are poised to reprogram at 72 h of OSKM expression 48 (Extended Data Fig
13,67 In this model, fracture of the endplate causes an immediate and broad up-regulation of pro-inflammatory cytokines in the NP and to a lesser extent in the AF
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Quinone compounds are notorious redox cyclers, present in drugs such as doxorubicin, which is used to treat a host of human cancers
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