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They found that piperazine erastin significantly decreased the size and number of tumor foci in the liver of DEN/CCl4-induced mice and the volume of Bel-7402 cell xenografts, accompanied by reduced levels of GPX4 expression
Trends Cancer 12 , 101104 (2026)
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The sensor is part of a protein that does triple duty: it senses, regulates, and delivers the antioxidant glutathione into the mitochondrial interior, where it plays critical roles in tamping down oxidizing reactions and maintaining appropriate iron levels
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