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Regular follow-up appointments allow healthcare professionals to assess response objectively through clinical evaluation and full blood count testing, rather than routinely rechecking B12 levels after treatment has begun

B-6 is essential for the utilization of proteins and fats, the production of red blood cells and antibodies, and the normal function of the nervous system

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Aminoglycosides, tetracyclines, and certain other antibiotics may alter gut microbiota composition, potentially affecting the small amount of vitamin B12 that is produced by colonic bacteria, though this is generally not clinically significant for patients receiving injectable B12 supplementation

There have been cases where forms of oral B12 supplements cause some discomfort in the stomach as it does not absorb the vitamin well