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Retatrutides safety profile is consistent with whats already been observed GLP-1 receptor agonists and combined GLP-1/GIP receptor agonists, meaning the expected side effects are primarily gastrointestinal (GI) in nature: Nausea, vomiting, diarrhea, and constipation
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Chang W, Zhang M, Li J, Meng Z, Wei S, Du H, Chen L, Hatch GM (2013) Berberine improves insulin resistance in cardiomyocytes via activation of 5-adenosine monophosphate-activated protein kinase
However, the authors suggest that future larger and longer trials are needed to fully assess the efficacy and safety of this treatment combination
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