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Most people do well with once-daily application of a 1-3% GHK-Cu product
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or features suggesting systemic illness or significant androgen excess
doi: 10.1016/j.envexpbot.2017.12.011 389 ZhaoW.ChenX.WangJ.ChengZ.MaX.ZhengQ.et al
Significant targets and the effects of PKGI in SMC are activation of myosin light chain phosphatase, inhibition of PLC, inhibition of the IP 3 receptor, inhibition of plasma membrane localized L-type Ca 2+ channels, and activation of plasma membrane localized calcium-activated K + channels (commonly called the big potassium, BK, channels)
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