is oral b12 as effective as injections Vitamin vs. Supplements: Which Works Best? Should You Use Sublingual B12

It also carries essentially no risk at the doses typically used in compounded formulations, making it a low-downside addition even when the benefit is uncertain

This is a safer approach because your body's natural feedback system stays intact

Aimee Bernard, PhD When any type of medicine undergoes clinical trials, they always have a protocol that they put in place, and they follow that protocol very specifically, said Bernard, PhD, an assistant professor at the University of Colorado School of Medicine Department of Immunology and Microbiology

Untreated vitamin B12 deficiencies can lead to neurological issues or pernicious anemia which can occur when your body does not have enough vitamin B12 to produce the amount of red blood cells it needs

note in Nature Medicine , NNMT inhibition has been shown to enhance energy expenditure and promote fat loss, even without dietary modification (Kraus et al., Nature Medicine )