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Jin et al
Subcutaneous administration in normal and metabolically dysregulated mice significantly inhibits NNMT activity in metabolically active tissues (adipose, liver, muscle), increases systemic NAD+ levels, enhances mitochondrial function, and improves energy metabolism
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Brain-derived growth factor and nerve growth factor concentrations are decreased in the substantia nigra in Parkinsons disease
It has been evaluated in controlled human trials using disease-specific endpoints, with published clinical safety data
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