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New Engl J Med (2021) 384:111324
The fullness signal is sent to the brain all day, even if youre eating less food that usual
This approach can be used alone or in tandem with GLP-1 agonists
A monomolecular coagonist (tirzepatide) of receptors for both incretin hormones (glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide) produced HbA1c values below 5.7% in 50% of the treated patients and weight losses exceeding 20% in obese individuals
Side Effects, Tolerability, and Dose Adjustment Nausea is the most frequent side effect during dose escalation, occurring in 2540% of patients in clinical trials
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