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This is more likely to happen if you already have sensitive or reactive skin
Kauvar KM
Additionally, iron is a cofactor for lipoxygenases (LOXs), enzymes that catalyze the oxidation of polyunsaturated fatty acids, leading to the production of lipid ROS, such as lipid hydroperoxides
Upon internalization into the tumor cells, GSH in the cytoplasm cleaves the disulfide bond within the polymer, triggering the CPT release and disassembly of the system which facilitated the immediate co-release of the DOX
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