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5-Amino-1MQ is a small molecule that acts as a potent inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT)
TB-500 reproduces the active region of that protein in a more stable synthetic form
Therefore, mutations in the PLPBP gene disrupt this process, causing PLP to react with other substrates and impacting the metabolism of important amine or amino acid neurotransmitters in the brain, consequently leading to the development of epilepsy
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